Anaplerosis in cancer: Another step beyond the warburg effect
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چکیده
منابع مشابه
Metabolic changes in cancer: beyond the Warburg effect.
Altered metabolism is one of the hallmarks of cancer cells. The best-known metabolic abnormality in cancer cells is the Warburg effect, which demonstrates an increased glycolysis even in the presence of oxygen. However, tumor-related metabolic abnormalities are not limited to altered balance between glucose fermentation and oxidative phosphorylation. Key tumor genes such as p53 and c-myc are fo...
متن کاملThe Warburg Effect and Beyond: Metabolic Dependencies for Cancer Cells
Abstract Current definitions of cancer are best realized as a list of traits or hallmarks, such as tissue invasion, metastasis, cell-autonomous growth, and resistance to apoptosis. A recent update included deregulated cellular energetics as an emerging hallmark. However, debate about tumor cell metabolism occupied center stage in the pre-oncogene era. Over the last 15 years, direct links of onc...
متن کاملBeyond Warburg effect – dual metabolic nature of cancer cells
Warburg effect is a dominant phenotype of most cancer cells. Here we show that this phenotype depends on its environment. When cancer cells are under regular culture condition, they show Warburg effect; whereas under lactic acidosis, they show a nonglycolytic phenotype, characterized by a high ratio of oxygen consumption rate over glycolytic rate, negligible lactate production and efficient inc...
متن کاملCancer Cell Metabolism: Warburg and Beyond
Described decades ago, the Warburg effect of aerobic glycolysis is a key metabolic hallmark of cancer, yet its significance remains unclear. In this Essay, we re-examine the Warburg effect and establish a framework for understanding its contribution to the altered metabolism of cancer cells.
متن کاملCancer metabolism: the Warburg effect today.
One of the first studies on the energy metabolism of a tumour was carried out, in 1922, in the laboratory of Otto Warburg. He established that cancer cells exhibited a specific metabolic pattern, characterized by a shift from respiration to fermentation, which has been later named the Warburg effect. Considerable work has been done since then, deepening our understanding of the process, with co...
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ژورنال
عنوان ژورنال: American Journal of Molecular Biology
سال: 2012
ISSN: 2161-6620,2161-6663
DOI: 10.4236/ajmb.2012.24031